Standard Oligonucleotide Modifications for custom DNA and RNA synthesis

Eurofins Genomics offers a wide variety of modifications for both DNA and RNA oligos to meet the needs of virtually any project. Modifications that are regularly stocked in-house are considered the "standard modifications portfolio." Standard modifications are listed below.

Non-standard modifications

Non-standard modifications refer to a.) custom modifications supplied by the customer, b.) special requests from customers for modifications not listed in the standard portfolio, and c.) modifications that we have prior expertise with but may not keep in stock due to the infrequency of orders. In short, any modification that is not listed in the standard portfolio. Eurofins Genomics can accommodate requests for non-standard modifications. We understand that much of science revolves around experimentation and new needs arise from new techniques.

            Do not see a modification you want? Contact us to request a modification.

Specifications

                                                  Pricing

Modification / Category

Designator

5'

Int

3'

DNA or RNA

Tubes or Plates

Max Abs (nm)

Max Em (nm)

Extinction coefficient (M-1cm–1)

25 nmole

50 nmole

250 nmole

1 µmole

2 µmole

5 µmole

10 µmole

Notes

Fluorophores

Alexa Fluor 350

[Alexa350]

DNA

T

346

424

19000

--

$653.00

$653.00

$1,686.00

$2,774.00

$6,935.00

--

Alternative to AMCA

CF 405S succinimidyl ester (CF405SN)

[CF405SN]

DNA

T

404

431

33000

--

--

$263.00

$1180.00

--

--

--

--

Tide Fluor 1

[TF1]

DNA

T

341

447

 

--

$140.00

$140.00

$248.00

$320.00

$800.00

$1,372.00

 

ATTO 390

[ATTO390]

DNA

T

390

479

24000

--

$152.00

$221.00

$305.00

$551.00

$1,448.75

--

 

5-FAM

[5FAM]

 

 

Both

T

492

518

 

--

$55.00

$70.00

$145.00

$158.00

$230.00

$525.00

Alternative to CY2, DY-495, ATTO 495

Alexa Fluor 488

[Alexa488]

DNA

T

496

519

71000

--

$300.00

$300.00

$450.00

$509.00

$778.05

--

 

Fluorescein

[FL]

 

DNA

T

495

520

83000

--

$65.00

$81.00

$175.00

$248.00

$452.00

--

Alternative to DY-495, ATTO 495

6-FAM

[FAM]

 

Both

Both

495

521

75000

--

$68.00

$85.00

$184.00

$239.00

$342.00

$525.00

 

Fluorescein dT

[FLUdT]

 

DNA

T

494

522

75000

--

$200.00

$225.00

$320.00

$359.10

$685.90

$1,600.00

Alternative to DY-495, ATTO 495

Tide Fluor 2

[TF2]

DNA

T

499

522

 

--

$140.00

$140.00

$248.00

$320.00

$800.00

$929.00

 

ATTO 488

[ATTO488]

DNA

T

501

523

90000

--

$205.00

$273.00

$378.00

$467.40

$718.20

--

Alternative to Cy2

Oregon Green 488

[OG488]

DNA

T

496

524

76000

--

$375.00

$375.00

$565.00

$638.40

$978.50

$5,750.00

Alternative to Cy2

TET

[TET]

 

 

Both

Both

519

539

86000

--

$75.00

$94.00

$190.00

$380.00

$950.00

$750.00

Alternative to CAL Fluor Gold 540

CAL Fluor Gold 540

[CalFluor540]

 

 

DNA

T

 

 

522

 

--

--

--

--

--

--

Alternative to 81100

JOE

[JOE]

DNA

T

520

548

73000

--

$205.00

$205.00

$310.00

 

 

$7,400.00

Alternative to CAL Fluor Gold 540, Rhodamine 6G

Yakima Yellow

[YAKYE]

 

 

DNA

T

530

549

 

--

$79.00

$100.00

$201.40

$265.00

$530.00

$1,060.00

Alternative to VIC, CAL Fluor 560

Alexa Fluor 532

[Alexa532]

DNA

T

532

553

81000

--

$375.00

$375.00

$565.00

$638.40

$978.50

$5,750.00

 

ATTO 532

[ATTO532]

DNA

T

532

553

115000

--

$205.00

$273.00

$378.00

$469.30

$718.20

--

 

HEX

[HEX]

 

 

Both

Both

537

556

96000

--

$75.00

$94.00

$190.00

$214.70

$324.90

$683.00

Alternative to VIC, CAL Fluor 560, SIMA

Alexa Fluor 555

[Alexa555]

DNA

T

555

565

150000

--

$653.00

$653.00

$1,686.00

$2,774.00

$6,935.00

--

Alternative to Cy3, TRITC & TMR, Alexa Fluor 546

Alexa Fluor 546

[Alexa546]

DNA

T

556

573

104000

--

$375.00

$375.00

$565.00

$633.65

$978.50

$5,750.00

 

ATTO 550

[ATTO550]

DNA

T

554

576

120000

--

$205.00

$273.00

$378.00

$467.40

$718.20

--

Alternative to NED, Cy3, Rhodamine B & 6G

TAMRA dT

[TAMdT]

 

DNA

T

544

576

90000

--

$156.00

$283.00

$422.00

$693.50

$1,733.75

--

 

Tide Fluor 3

[TF3]

DNA

T

554

578

 

--

$140.00

$140.00

$248.00

$320.00

$800.00

$929.00

 

TAMRA

[TAM]

 

 

DNA

Both

556

580

89000

--

$98.00

$115.00

$175.00

$194.75

$299.25

$780.00

Alternative to Rhodamine 6G, Rhodamine B, CAL Fluor 590

5-Tamra (ester)

[TMR5]

 

 

DNA

T

557

583

 

--

$130.00

$155.00

$250.00

$279.30

$738.15

$1,700.00

 

CAL Fluor 590

[CalFluor590]

 

 

DNA

T

569

591

79000

--

350.00 

$350.00

$455.00

$865.50

$2,161.25

$3,640.00

 

ATTO 565

[ATTO565]

DNA

T

563

592

120000

--

$174.00

$263.00

$352.00

$435.10

$668.80

--

Alternative to PET, Alexa Fluor 594

ROX

[ROX]

DNA

T

575

602

82000

--

$174.00

$174.00

$263.00

$324.90

$498.75

$1,790.00

Alternative to Texas Red, Alexa Fluor 594, CAL Fluor Red 610

Alexa Fluor 568

[Alexa568]

DNA

T

578

603

91000

--

$653.00

$653.00

$1,686.00

$2,774.00

$6,935.00

--

 

Texas Red

[TxRed]

DNA

T

583

603

116000

--

$200.00

$242.00

$347.00

$428.25

$658.35

--

Alternative to ROX, Alexa Fluor 594

Cyanine3.5 dye

[Cy35]

 

DNA

T

591

604

116000

--

$173.00

$185.00

$294.00

$532.50

$1,330.00

--

Alternative to Alexa Fluor 594, CAL Fluor Red 610

CAL Fluor Red 610

[CalFluor610]

 

 

DNA

T

590

610

108000

--

$350.00

$350.00

$455.00

$865.50

$2,161.25

$3,640.00

Alternative to Texas Red, ROX, Alexa Fluor® 594

Tide Fluor 4

[TF4]

DNA

T

588

610

 

--

$140.00

$140.00

$248.00

$320.00

$800.00

$929.00

 

Alexa Fluor 594

[Alexa594]

DNA

T

590

617

73000

--

$440.00

$440.00

$670.00

$753.35

$2,498.00

$6,450.00

Alternative to ATTO 594, CAL Fluor Red 610

ATTO 590

[ATTO590]

DNA

T

594

624

120000

--

$174.00

$263.00

$352.00

$434.15

$668.80

--

 

Alexa Fluor 633

[Alexa633]

DNA

T

632

647

239000

--

$653.00

$653.00

$1,686.00

$2,774.00

$6,935.00

--

 

ATTO 633

[ATTO633]

DNA

T

629

657

130000

--

$205.00

$273.00

$378.00

$467.40

$718.20

--

Alternative to LIZ, Alexa Fluor 633

Cyanine5 dye

[Cy5]

 

 

Both

T

646

662

250000

--

$107.00

$135.00

$210.00

$233.70

$489.25

$1,300.00

Alternative to Quasar 670, TYE 655, TYE 665

Alexa Fluor 647

[Alexa647]

DNA

T

650

665

239000

--

$300.00

$300.00

$450.00

$504.45

$778.05

--

Alternative to Cy5, Quasar 670

ATTO 647N

[ATTO647N]

DNA

T

644

669

150000

--

$205.00

$273.00

$378.00

$467.40

$718.20

--

Alternative to Cy5, Quasar 670

Tide Fluor 5

[TF5]

DNA

T

656

670

 

--

$140.00

$140.00

$248.00

$320.00

$800.00

$929.00

 

ATTO 655

[ATTO655]

DNA

T

663

684

125000

--

$152.00

$221.00

$305.00

$579.50

$1,448.75

--

 

Alexa Fluor 660

[Alexa660]

DNA

T

663

690

132000

--

$440.00

$440.00

$670.00

$753.35

$1,154.25

$6,450.00

 

Alexa Fluor 680

[Alexa680]

DNA

T

679

702

184000

--

$653.00

$653.00

$1,686.00

$2,774.00

$6,935.00

--

Alternative to Alexa Fluor 680, Alexa Fluor 700

Tide Fluor 6

[TF6]

DNA

T

686

702

 

--

$140.00

$140.00

$248.00

$320.00

$800.00

$929.00

 

Cyanine5.5 dye

[Cy55]

 

 

DNA

T

688

707

209000

--

$184.00

$205.00

$310.00

$294.50

$589.00

$3,100.00

Alternative to Alexa Fluor 680, TYE 705

ATTO 700

[ATTO700]

DNA

T

700

719

120000

--

$152.00

$221.00

$305.00

$579.50 

$1448.75 

--

 

Alexa Fluor 700

[Alexa700]

DNA

T

702

723

192000

--

$653.00

$653.00

$1,686.00

$2,774.00

$6,935.00

--

Alternative to IRDye 700, Quasar 705

ATTO 740

[ATTO740]

DNA

T

740

764

120000

--

$145.00

$210.00

$290.00

--

--

--

Alternative to Cy7, Alexa Fluor 740

Alexa Fluor 750

[Alexa750]

DNA

T

749

775

240000

--

$440.00

$440.00

$670.00

$753.35 

$1154.25 

--

 

Tide Fluor 7

[TF7]

DNA

T

756

775

 

--

$140.00

$140.00

$248.00

$320.00

$800.00

$929.00

 

Tide Fluor 8

[TF8]

DNA

T

787

808

 

--

$140.00

$140.00

$248.00

$320.00

$800.00

$929.00

 

Quenchers

BBQ650

[BBQ650]

 

DNA

T

650

n/a

33000

 

$257.25

$257.25

$294.00

$588.00

$1470.00

 

 

BHQ1

[BHQ1]

 

DNA

T

534

n/a

34000

--

$110.00

$145.00

$210.00

$359.10

$1005.00

$2000.00

 

BHQ1 dT

[BHQ1dT]

 

DNA

T

534

n/a

34000

--

--

$163.00

$252.00

$480.00

$1,200.00

--

 

BHQ2

[BHQ2]

 

DNA

T

579

n/a

91000

--

$110.00

$145.00

$210.00

$270.75

$359.10

$2000.00

 

BHQ2 dT

[BHQ2dT]

 

DNA

T

579

n/a

91000

--

--

$278.00

$383.00

$693.50

$1,733.75

--

 

Dabcyl STANDARD

[DAB}

 

 

DNA

T

453

n/a

32000

 

$92.00

$115.00

$175.00

$194.75

$374.30

$865.00

 

Dabcyl dT

[DABdT]

 

DNA

T

478

n/a

32000

--

$285.00

$382.50

$382.50

$690.00

$1,725.00

--

 

TAMRA

[TAM]

 

DNA

T

557

n/a

91000

--

$98.00

$115.00

$175.00

$194.75

$299.25

$780.00

 

Tide Quencher 1

[TQ1]

 

 

DNA

T

490

n/a

20000

--

$46.00

$58.00

$116.00

$200.00

$375.00

$635.00

 

Tide Quencher 2

[TQ2]

 

 

DNA

T

515

n/a

21000

--

$46.00

$58.00

$116.00

$200.00

$375.00

$635.00

 

Tide Quencher 3

[TQ3]

 

 

DNA

T

570

n/a

22000

--

$46.00

$58.00

$116.00

$200.00

$375.00

$635.00

 

Tide Quencher 5

[TQ5]

 

 

DNA

T

670

n/a

24000

--

$46.00

$58.00

$116.00

$200.00

$375.00

$635.00

 

 

Specifications

                                                  Pricing

Modification / Category

Designator

5'

Int

3'

DNA or RNA

Tubes or Plates

25 nmole

50 nmole

250 nmole

1 µmole

2 µmole

5 µmole

10 µmole

Notes

Mixed/Degenerate Bases (Wobbles)

N (A+C+G+T) Wobble

N

Both

Both

$0.38

$0.50

$1.26

$2.57

 

 

$17.00

N = (A, 25%; C, 25%; G, 25%; T, 25%)

B (C+G+T) Wobble

B

Both

Both

$0.38

$0.50

$1.27

$2.58

 

 

$17.01

B = (C, 33.3%; G, 33.3%; T, 33.3%)

D (A+G+T) Wobble

D

Both

Both

$0.38

$0.50

$1.28

$2.59

 

 

$17.02

D = (A-33.3%, G-33.3%, T-33.3%)

H (A+C+T) Wobble

H

Both

Both

$0.38

$0.50

$1.29

$2.60

 

 

$17.03

H = (A, 33.3%; C, 33.3%; T, 33.3%)

V (A+C+G) Wobble

V

Both

Both

$0.38

$0.50

$1.30

$2.61

 

 

$17.04

V = (A, 33.3%; C, 33.3%; G, 33.3%)

K (G+T) Wobble

K

Both

Both

$0.38

$0.50

$1.31

$2.62

 

 

$17.05

K = (G, 50%; T, 50%)

M (A+C) Wobble

M

Both

Both

$0.38

$0.50

$1.32

$2.63

 

 

$17.06

M = (A, 50%; C, 50%)

R (A+G)(purines) Wobble

R